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Weight loss is an important factor in type 2 diabetes management and is often complicated by diabetic agents that promote weight gain (i.e., sulfonylureas, thiazolidinediones (TZDs), insulin)

The MetroHealth System, Cleveland, Ohio, institutional review board determined research using TriNetX, in the way described here, is not human subject research, and therefore institutional review board approval was not required and the requirement for informed consent was waived

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Acknowledgements The authors thank L Johnson, L Wilkins, S Bound, S Oliver, J Martin, R Meeny, N Blasch, and F Dabrowski for animal care, S Holloway and J House for veterinary care, L Potenza and C Burstrm for excellent technical assistance, and A Samson for insightful advice